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Basic Science of Meniscal Repair

Thomas Annandale was credited with the first surgical repair of a torn meniscus in 1883 . It was not until 1936, when King published his classic experiment on meniscus healing in dogs, that the actual biological limitations of meniscus healing were set forth. King demonstrated that for meniscal lesions to heal, they must communicate with the peripheral blood supply.

Enhancing vascularity at or near the site of meniscal injury has remained a major focus in the techniques of surgical repair. In addition, advances in cellular and molecular biology now allow researchers to investigate the role of specific growth factors and cytokines in the cellular response to injury. Further application of these findings will continue to provide for means of enhancing meniscal repairs.

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