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Cellular Response to Injury

The ability of fibrochondrocytes within a meniscus to mount a reparative response is dependent in part upon cellular activity. Cytokines and growth factors present during the inflammatory response to injury may promote meniscal healing through enhancement of cell migration, cell division, and the production of extracellular matrix.

While no specific growth factor has been shown to enhance meniscus healing, researchers are beginning to identify how the meniscal fibrochondrocyte responds to various growth factors. Meniscal repair augmentation methods such as fibrin clot and platelet rich plasma (PRP) are based upon the concept that growth factors positively impact meniscal healing. Understanding which growth factors positively impact the healing potential of the meniscal fibrochondrocyte matrix will undoubtedly provide future strategies for treating meniscal injuries.

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