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A Patient’s Guide to Nutrition and Surgery

General surgery nutrition

General surgery nutrition

Introduction

Surgery always means a certain amount of risk to your well being. Surgery is a deliberate, skillful injury to your body. It may take you several weeks to months to heal. Infections and blood loss are two possible complications that your surgeon will want to help you avoid. […]

Collagen Cross-Links

Stabilization of collagen occurs extracellularly, after its assembly into the quarter-stagger arrays that make up filaments, fibrils, and fibers. The stabilization and ultimate tensile strength of the fiber structure are thought to result mainly from the development of intramolecular and intermolecular cross-links.

The former occur between α chains of the individual tropocollagen molecule and the […]

Crosslinking

Intramolecular and Intermolecular Crosslinks

Crosslinking renders the collagen fibers stable and provides them with a degree of tensile strength and visco-elasticity adequate to perform their structural role. The degree of crosslinking, the number and density of the fibers in a particular tissue, and the orientation and diameter combine to provide this function.

Crosslinking begins with […]

Translational, Cotranslational, and Early Post-translational Events

After the gene is transcribed, it is spliced to remove introns and to yield a functional mRNA that contains about 3,000 bases. Specific mRNAs for each chain and collagen type are translocated to the cytoplasm and translated into proteins in the rough endoplasmic reticulum (RER) on membrane-bound polysomes.

As the collagen polypeptide is synthesized in […]