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Paget Disease

Basics Description First described by Sir James Paget in 1877 , Paget disease (osteitis deformans) is a bone disorder commonly seen in the geriatric population. As implied by the name osteitis deformans, the involved bone may be severely deformed and enlarged, features that suggest an inflammatory origin. A chronic and slowly progressive disease of […]

Multiple Myeloma

Basics Description The most common of the plasma cell dyscrasias (usually with a monoclonal gammopathy) affecting the hematopoietic, musculoskeletal, and renal systems. Classification (plasma cell dyscrasias): Solitary myeloma Multiple myeloma Osteosclerotic myeloma Synonyms: Myeloma; Plasmacytoma Epidemiology Rare in patients <40 years old The Male:Female ratio is ~2:1. The peak age is the 6th decade […]