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Collagen Metabolism

Collagen is the most abundant of all body proteins. Tissues such as bone, which are involved in active remodeling, are responsible for the major turnover. Other less dynamic tissues in the full-grown individual, such as skin and tendons, may exhibit slow and almost negligible turnover. The collagen synthesizing activity of cells is usually assessed by their ability to synthesize hydroxyproline or by the activities of specific enzymes such as the proline and lysyl hydroxylases.

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