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Lysyl Oxidase

Recently formed microfibrils seem to be recognized by the enzyme lysyl oxidase, which converts certain peptide-bound lysines and hydroxylysines to aldehydes. The enzyme is an extracellular amine oxidase, which has been purified from a variety of connective tissues. It requires Cu2+ and probably pyridaxal as cofactors; molecular oxygen seems to be the cosubstrate, and hydrogen acceptor.

It is irreversibly inhibited by the lathyrogen BAPN (β-amino pro-pronitrile, a substance found in the flowering sweet-pea, lathyrusodoratus). This enzyme exhibits maximal activity when acting on collagen fibrils rather than upon monomeric collagen.

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